Are we sedating more than just the brain?
نویسندگان
چکیده
Heavy sedation in the ICU is associated with coma, delirium, and prolonged stays, but links between sedatives and non-brain organ failure have rarely been described. In a post hoc analysis, Strøm and colleagues explored associations between sedation and acute kidney injury among ICU patients randomly assigned to one of two sedation strategies. The 'no sedation' protocol was associated with less kidney injury, but methodologic limitations preclude firm conclusions regarding mechanisms underlying this association. This hypothesis-generating study warns that sedation may harm organs other than the brain during critical illness, a possibility that warrants careful study in the future.
منابع مشابه
High Stakes Require More Than Just Talk: What to Do About Corruption in Health Systems; Comment on “We Need to Talk About Corruption in Health Systems”
Reluctance to talk about corruption is an important barrier to action. Yet the stakes of not addressing corruption in the health sector are higher than ever. Corruption includes wrongdoing by individuals, but it is also a problem of weak institutions captured by political interests, and underfunded, unreliable administrative systems and healthcare delivery models. We ur...
متن کاملJust Noticeable Difference Estimation Using Visual Saliency in Images
Due to some physiological and physical limitations in the brain and the eye, the human visual system (HVS) is unable to perceive some changes in the visual signal whose range is lower than a certain threshold so-called just-noticeable distortion (JND) threshold. Visual attention (VA) provides a mechanism for selection of particular aspects of a visual scene so as to reduce the computational loa...
متن کاملUsing Combination of μ,β and γ Bands in Classi.cation of EEG Signals
Introduction: In most BCI articles which aim to separate movement imaginations, µ and &beta frequency bands have been used. In this paper, the effect of presence and absence of &gamma band on performance improvement is discussed since movement imaginations affect &gamma frequency band as well. Methods: In this study we used data set 2a from BCI Competition IV. In this data set, 9 healthy sub...
متن کاملKernicterus in Two Generations: A Need for More Aggressive Preventive Measures
Bilirubin induced brain damage is still a common cause of morbidity and mortality in Nigerian infants. No much success has been recorded in decades despite the fact that brain damage from bilirubin toxicity in the newborn is easily preventable with affordable and effective means. We report a case of a newborn with acute bilirubin encephalopathy. This case was considered of interest because the ...
متن کاملGenerating Synthetic Computed Tomography and Synthetic Magnetic Resonance (sMR: sT1w/sT2w) Images of the Brain Using Atlas-Based Method
Introduction: Nowadays, magnetic resonance imaging (MRI) in combination with computed-tomography (CT) is increasingly being used in radiation therapy planning. MR and CT images are applied to determine the target volume and calculate dose distribution, respectively. Since the use of these two imaging modalities causes registration uncertainty and increases department w...
متن کامل